ABT-414, an Antibody–Drug Conjugate Targeting a Tumor-Selective EGFR Epitope
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چکیده
منابع مشابه
ABT-414, an Antibody-Drug Conjugate Targeting a Tumor-Selective EGFR Epitope.
Targeting tumor-overexpressed EGFR with an antibody-drug conjugate (ADC) is an attractive therapeutic strategy; however, normal tissue expression represents a significant toxicity risk. The anti-EGFR antibody ABT-806 targets a unique tumor-specific epitope and exhibits minimal reactivity to EGFR in normal tissue, suggesting its suitability for the development of an ADC. We describe the binding ...
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ژورنال
عنوان ژورنال: Molecular Cancer Therapeutics
سال: 2016
ISSN: 1535-7163,1538-8514
DOI: 10.1158/1535-7163.mct-15-0901